check out this paper in Cancer Cell, by Robyn Ward's group from down under --see it here
Dominantly
Inherited Constitutional Epigenetic Silencing of MLH1 in a
Cancer-Affected Family Is Linked to a Single Nucleotide Variant within
the 5'UTR.
Hitchins MP, Rapkins RW, Kwok CT, Srivastava S, Wong JJ, Khachigian LM, Polly P, Goldblatt J, Ward RL.
Source
Adult
Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical
School, Faculty of Medicine at the University of New South Wales, NSW
2052, Australia.
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