Hello! you have reached the official blog spot of our lab which is based at the University of Texas Health Science Center at San Antonio, Department of Urology - our main area of study is prostate cancer, nutrition, and epigenetics - but we also study changes in gene expression in benign-prostatic hyperplasia - we have made this blog so as we can share thoughts about the lab, papers that are just published and anything else remotely relevant at any time, and from anywhere!
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Friday, October 7, 2011
A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript.
Andy Feinberg and Paddy Onyango have just published (gasp) the long-sought after, real WT2 (Wilm's Tumor) locus....and it encodes "HOTS" the H19 opposite tumor suppressor - which is maternally expressed. The paper, in PNAS demonstrates beautifully how easy it is to miss something that was right there all along - read about it for yourself, for FREE at Onyango and Feinberg, PNAS
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