Hello! you have reached the official blog spot of our lab which is based at the University of Texas Health Science Center at San Antonio, Department of Urology - our main area of study is prostate cancer, nutrition, and epigenetics - but we also study changes in gene expression in benign-prostatic hyperplasia - we have made this blog so as we can share thoughts about the lab, papers that are just published and anything else remotely relevant at any time, and from anywhere!
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Monday, April 30, 2012
Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent.
In this manuscript published in The Prostate, Ching-Shih Chen's group from Ohio State show that energy restriction (either by novel mimetics or 2-deoxyglucose), led to down-regulation of DNMT1 and 3A (DNA methyltransferases 1 and 3A) and subsequent reactivation of previously hypermethylated tumor suppressor genes - caloric restriction has been shown to suppress cancer in animal models, but these findings provide a novel mechanism for the effect -- read it for yourself at http://onlinelibrary.wiley.com/doi/10.1002/pros.22530/pdf
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