Genes Dev. 2011 Aug 1;25(15):1583-8.
Polycomb eviction as a new distant enhancer function.
Vernimmen D
, Lynch MD
, De Gobbi M
, Garrick D
, Sharpe JA
, Sloane-Stanley JA
, Smith AJ
, Higgs DR
.
Abstract
Remote distal
enhancers may be located tens or thousands of kilobases away from their
promoters. How they control gene expression is still poorly understood.
Here, we analyze the influence of a remote enhancer on the balance
between repression (Polycomb-PcG) and activation (Trithorax-TrxG) of a
developmentally regulated gene associated with a CpG island. We reveal
its essential, nonredundant role in clearing the PcG complex and
H3K27me3 from the CpG island. In the absence of the enhancer, the
H3K27me3 demethylase (JMJD3) is not recruited to the CpG island. We
propose a new role of long-range regulatory elements in removing
repressive PcG complexes.
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