A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript.

Andy Feinberg and Paddy Onyango have just published (gasp) the long-sought after, real WT2 (Wilm's Tumor) locus....and it encodes "HOTS" the H19 opposite tumor suppressor - which is maternally expressed.  The paper, in PNAS demonstrates beautifully how easy it is to miss something that was right there all along - read about it for yourself, for FREE at Onyango and Feinberg, PNAS