Hello! you have reached the official blog spot of our lab which is based at the University of Texas Health Science Center at San Antonio, Department of Urology - our main area of study is prostate cancer, nutrition, and epigenetics - but we also study changes in gene expression in benign-prostatic hyperplasia - we have made this blog so as we can share thoughts about the lab, papers that are just published and anything else remotely relevant at any time, and from anywhere!
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Showing posts with label Hanson Data on MLVs in ME/CFS. Show all posts
Showing posts with label Hanson Data on MLVs in ME/CFS. Show all posts
Tuesday, May 22, 2012
Novel MLV-GAG sequences detected in blood samples of ME/CFS patients
From the Hanson lab, this paper published today in PLoS ONE describes a study carried out with meticulous attention to detail and proper use of controls while analyzing ME/CFS patient samples for murine-leukemia related viruses. Although novel MLV-like GAG sequences were isolated and sequenced from the patient samples (as opposed to controls collected from the same sites) Lee et al. concludes that it is not possible to determine the origin of these sequences, although the samples were not contaminated with mouse DNA at a detectable level. First, bravo! to the Hanson group for being able to get anything published that might go against the current dogma regarding MLV-like viruses in human samples published -- I guarantee you that there are people with similar data whom don't want to torture themselves by attempting to publish. The fact is, that it seems somehow MLV-like nucleic acids somehow end up in patient samples quite a bit, albeit at exceedingly low levels. Theoretically, even if there was an MLV-type infection in a human, it would be rapidly eliminated (unless of course we don't know everything about the immune system yet). I wonder if it is possible that such viruses could hide somewhere in the body, not replicating much - perhaps killing host cells occasionally resulting in a release of (potentially degraded) viral nucleic acid that is ultimately detected in the blood stream. I haven't analyzed these sequences yet compared to those we have detected in tissue samples from BPH patients, but seeing as our sequences were recently published on the USPTO website, someone else will probably try that. The link to the Hanson paper is here --
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