Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent.

In this manuscript published in The Prostate, Ching-Shih Chen's group from Ohio State show that energy restriction (either by novel mimetics or 2-deoxyglucose), led to down-regulation of DNMT1  and 3A (DNA methyltransferases 1 and 3A) and subsequent reactivation of previously hypermethylated tumor suppressor genes - caloric restriction has been shown to suppress cancer in animal models, but these findings provide a novel mechanism for the effect -- read it for yourself at http://onlinelibrary.wiley.com/doi/10.1002/pros.22530/pdf