Inhibition of HIV-1 and dengue virus replication with a common dog medicine!

In this paper from down-under, the novel finding that Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import, and able to inhibit replication of HIV-1 and dengue virus -- ivermectin -- yep, that is the stuff that we give our dogs every month to prevent heartworm...although all the experiments here are in vitro and at high drug concentrations, these findings are interesting because they could provide the basis for future drug design as well drug target(s) --  the manuscript is open access - read all about it here -- by Wagstaff et al.