Friday, November 18, 2011

Global DNA Demethylation During Mouse Erythropoiesis in Vivo

Previously, it was thought that global DNA demethylation just occurs in germ cells and the preimplantation embryo, however here, Socolovsky's lab at U Mass show that in fact, global demethylation of DNA occurs during erythropoiesis (red cell development), and that it is dependent on replication - which is contrary to the idea of active DNA demethylation that has been put forward in some models.  Read about it in today's Science magazine Shearstone et al.

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