Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells

In an interesting manuscript from the Kong lab at Rutgers, MeCP2 was excluded from binding the Neurog1 promoter in LNCaP cells treated with curcumin...this would present a novel mechanism for curcumin action and leaves open the question of how specific gene promoters are targeted for de-methylation.  You can read the paper here

http://www.springerlink.com/content/vn70663150u83456/