Friday, September 2, 2011

Single nucleotide polymorphisms that "attract" methylation -- a novel mechanism for inherited cancer susceptibility?

check out this paper in Cancer Cell, by Robyn Ward's group from down under --see it here

Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5'UTR.

Hitchins MP, Rapkins RW, Kwok CT, Srivastava S, Wong JJ, Khachigian LM, Polly P, Goldblatt J, Ward RL.


Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, Faculty of Medicine at the University of New South Wales, NSW 2052, Australia.

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