Hello! you have reached the official blog spot of our lab which is based at the University of Texas Health Science Center at San Antonio, Department of Urology - our main area of study is prostate cancer, nutrition, and epigenetics - but we also study changes in gene expression in benign-prostatic hyperplasia - we have made this blog so as we can share thoughts about the lab, papers that are just published and anything else remotely relevant at any time, and from anywhere!
Thursday, August 18, 2011
new addition for the emergency reading list...
Genes Dev. 2011 Aug 1;25(15):1583-8.
Polycomb eviction as a new distant enhancer function.
Vernimmen D, Lynch MD, De Gobbi M, Garrick D, Sharpe JA, Sloane-Stanley JA, Smith AJ, Higgs DR.
enhancers may be located tens or thousands of kilobases away from their
promoters. How they control gene expression is still poorly understood.
Here, we analyze the influence of a remote enhancer on the balance
between repression (Polycomb-PcG) and activation (Trithorax-TrxG) of a
developmentally regulated gene associated with a CpG island. We reveal
its essential, nonredundant role in clearing the PcG complex and
H3K27me3 from the CpG island. In the absence of the enhancer, the
H3K27me3 demethylase (JMJD3) is not recruited to the CpG island. We
propose a new role of long-range regulatory elements in removing
repressive PcG complexes.